RNA Details
Disease Name
Pulmonary Disease Chronic Obstructive
Tissue
lung
RNA Symbol
Cdkn2a
RNA ID
RNA Type
mRNA
Alteration Pattern
promoter hypermethylation
Species
rattus norvegicus
Detection Methods
qRT-PCR; Immunohistochemistry etc.
Target
NA
Pathway
NA
PubMed ID
Title
Detection of p16 promoter methylation in premature rats with chronic lung disease induced by hyperoxia
Year
2010
Function
"Exposure to hyperoxia may induce p16 promoter hypermethylation in lung tissues in premature rats, and methylation risk increases as exposure extends. P16 promoter methylation induced by hyperoxia may be one of the mechanisms for low p16 mRNA and protein expression."